CERTIFICATE OF ANALYSIS
PRODUCT NAME:TRIFLUROACETIC ACID
CAS NO:76-05-1
FORMULA:C2HF3O2
MELTING POINT:-15.4 °C
BOILING POINT :72.4 °C
MOLAR MASS:114.02 g/mol
IUPAC ID:2,2,2-Trifluoroacetic acid
DENSITY:1.49 g/cm³
INFORMATION OF TRIFLUROACETIC ACID:Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CF3CO2H. It is a colorless liquid with a sharp odor similar to vinegar, but stronger in acidity. TFA is an analogue of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. The acidity of TFA is approximately 34,000 times stronger[2] than that of acetic acid due to the electronegativity of thetrifluoromethyl group. TFA is widely used in organic chemistry for various purposes.
USES:TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride and 2,2,2-trifluoroethanol.[3] It is areagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an acid.[7] TFA is also less oxidizing than sulfuric acid but more readily available in anhydrous form than many other acids. One complication to its use is that TFA forms an azeotrope with water (b. p. 105 °C).
PRODUCT NAME:TRIFLUROACETIC ACID
CAS NO:76-05-1
FORMULA:C2HF3O2
MELTING POINT:-15.4 °C
BOILING POINT :72.4 °C
MOLAR MASS:114.02 g/mol
IUPAC ID:2,2,2-Trifluoroacetic acid
DENSITY:1.49 g/cm³
INFORMATION OF TRIFLUROACETIC ACID:Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CF3CO2H. It is a colorless liquid with a sharp odor similar to vinegar, but stronger in acidity. TFA is an analogue of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. The acidity of TFA is approximately 34,000 times stronger[2] than that of acetic acid due to the electronegativity of thetrifluoromethyl group. TFA is widely used in organic chemistry for various purposes.
USES:TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride and 2,2,2-trifluoroethanol.[3] It is areagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an acid.[7] TFA is also less oxidizing than sulfuric acid but more readily available in anhydrous form than many other acids. One complication to its use is that TFA forms an azeotrope with water (b. p. 105 °C).
TFA is popularly used as a strong acid in peptide synthesis and other organic synthesis to remove the t-butoxycarbonyl protecting group.[8][9]
At a low concentration, TFA is used as an ion pairing agent in liquid chromatography (HPLC) of organic compounds, particularlypeptides and small proteins. TFA is a versatile solvent for NMR spectroscopy (for materials stable in acid). It is also used as a calibrant in mass spectrometry.[10]